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DOI: 10.1055/s-0034-1385930
Non-Glutamatergic Clozapine Augmentation Strategies: A Review and Meta-Analysis
Publication History
received 14 May 2014
revised 14 May 2014
accepted 15 July 2014
Publication Date:
14 August 2014 (online)
![](https://www.thieme-connect.de/media/pharmaco/201407/lookinside/thumbnails/10.1055-s-0034-1385930-1.jpg)
Abstract
Persistent negative symptoms and cognitive impairment are major clinical problems in the treatment of schizophrenia. There is no convincing evidence regarding the efficacy of augmentation of clozapine with a second antipsychotic, ethyl eicosapentaenoic acid (E-EPA), an antidepressant, a mood stabilizer or extract of Ginkgo biloba in clozapine-resistant schizophrenia. We present an overview of studies in which the potential clinical utility of the addition of non-glutamatergic agents to clozapine is assessed. We performed a meta-analysis on the efficacy of both risperidone and aripiprazole compared to placebo. We compared the effects of the addition of a second antipsychotic or an antidepressant to clozapine on positive, negative, overall and affective symptoms of schizophrenia in double-blind placebo-controlled trials.
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