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DOI: 10.1055/s-0034-1384561
Comparative Study of Three Traditional Mongolian Medicines on Streptozotocin-induced Diabetic Nephropathy in Rats
Publication History
received 26 April 2014
accepted 16 May 2014
Publication Date:
22 July 2014 (online)
![](https://www.thieme-connect.de/media/drugres/201506/lookinside/thumbnails/2014-04-0704_10-1055-s-0034-1384561-1.jpg)
Abstract
3 kinds of prescription of Traditional Mongolian (Chinese) Medicine (TMM) have been used in treating diabetic nephropathy (DN). We aimed to investigate: first, which prescription was more effective; second, whether it was more effective when combined with the 3 prescriptions. The DN model was prepared by a single dose of Streptozotocin (STZ, 65 mg/kg, i.p.) in rats and treated 3 times every day with P-1 (Sugmul-10), P-2 (Narenmandul-11), P-3 (Xieriga-4) respectively, and combined group was treated with P-1 in the morning, P-2 and P-3 in the evening. The results showed combining with 3 prescriptions in one day was much more effective than each single prescription. The mechanism of renal protection maybe related to MMP-2 and TGF-β1, the conclusion could be useful and beneficial for clinical medicine.
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