Synlett 2015; 26(09): 1276-1280
DOI: 10.1055/s-0034-1380381
letter
© Georg Thieme Verlag Stuttgart · New York

A Grignard-Type Phase-Vanishing Method: Generation of Organomagnesium Reagent and Its Subsequent Addition to Carbonyl Compounds

Hiroshi Matsubara*
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan   eMail: matsu@c.s.osakafu-u.ac.jp
,
Yuki Niwa
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan   eMail: matsu@c.s.osakafu-u.ac.jp
,
Ryosuke Matake
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan   eMail: matsu@c.s.osakafu-u.ac.jp
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Publikationsverlauf

Received: 19. Januar 2015

Accepted after revision: 16. Februar 2015

Publikationsdatum:
30. März 2015 (online)


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Abstract

A quadraphasic phase-vanishing system comprised of diethyl ether, magnesium, perfluoropolyether, and iodoalkane efficiently generated the corresponding Grignard reagents, which subsequently added to carbonyl compounds in the ether layer to afford alkylated alcohols in good yields.

Supporting Information