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Synlett 2015; 26(09): 1276-1280
DOI: 10.1055/s-0034-1380381
DOI: 10.1055/s-0034-1380381
letter
A Grignard-Type Phase-Vanishing Method: Generation of Organomagnesium Reagent and Its Subsequent Addition to Carbonyl Compounds
Weitere Informationen
Publikationsverlauf
Received: 19. Januar 2015
Accepted after revision: 16. Februar 2015
Publikationsdatum:
30. März 2015 (online)


Abstract
A quadraphasic phase-vanishing system comprised of diethyl ether, magnesium, perfluoropolyether, and iodoalkane efficiently generated the corresponding Grignard reagents, which subsequently added to carbonyl compounds in the ether layer to afford alkylated alcohols in good yields.
Key words
fluorous solvent - phase-vanishing - Grignard reaction - Barbier reaction - magnesium - perfluoropolyetherSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380381.
- Supporting Information