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Synthesis 2015; 47(09): 1348-1355
DOI: 10.1055/s-0034-1379898
DOI: 10.1055/s-0034-1379898
paper
Total Synthesis of (+)-Clavulatriene A
Further Information
Publication History
Received: 13 January 2015
Accepted after revision: 02 February 2015
Publication Date:
05 March 2015 (online)


Abstract
The protecting-group-free total synthesis of (+)-clavulatriene A has been achieved. Key features of the synthetic strategy include the development of a novel strategy for the practical synthesis of α-cyperone, and a one-pot palladium-catalyzed reductive desulfonylation and deacetoxylation reaction. Furthermore, the total synthesis described in this study allowed for the determination of the absolute configuration of (+)-clavulatriene A.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1379898.
- Supporting Information