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Eur J Pediatr Surg 2014; 24(03): 219-226
DOI: 10.1055/s-0034-1378150
Review
Georg Thieme Verlag KG Stuttgart · New York

Stem Cell Therapy as an Option for Pediatric Surgical Conditions

Augusto Zani
1   Department of Paediatric Surgery, University College London Institute of Child Health, London, United Kingdom
,
Paolo De Coppi
1   Department of Paediatric Surgery, University College London Institute of Child Health, London, United Kingdom
2   Department of Surgery, Great Ormond Street Hospital for Children, London, United Kingdom
› Author Affiliations
Further Information

Publication History

19 April 2014

23 April 2014

Publication Date:
19 June 2014 (online)

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Abstract

Regenerative medicine aims to replace, repair, or restore normal function of cells, tissues, and organs that are damaged by disease and holds a promising potential for the treatment of congenital anomalies. Herein, we present an overview of the different stem cell populations and discuss the potentials and most recent updates in stem cell therapy relevant to pediatric surgeons. In particular, we focus on stem cell applications in intestinal regeneration for necrotizing enterocolitis, liver regeneration in biliary atresia and human hepatocyte transplantation for liver failure, and pulmonary regeneration of hypoplastic lungs due to prematurity or congenital diaphragmatic hernia.

Keywords

regenerative medicine - stem cell - amniotic fluid - mesenchymal stem cells - NEC
 

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