Psychother Psychosom Med Psychol 2015; 65(02): 58-65
DOI: 10.1055/s-0034-1376971
Originalarbeit
© Georg Thieme Verlag KG Stuttgart · New York

Stressreaktivität vor und nach integrierter akutpsychosomatischer Komplexbehandlung

Stability of Mental Stress-induced Hemodynamic and Autonomic Reaction despite Successful Treatment for Psychosomatic Disorder
Jana Lomb
1   Abteilung für Allgemein- und Viszeralchirurgie, Klinikum Kemperhof, Gemeinschaftsklinikum Koblenz-Mayen, Koblenz
,
Christina Kleiber
2   Klinik für Psychosomatische Medizin und Psychotherapie, Universitätsmedizin Göttingen
,
Christoph Herrmann-Lingen
2   Klinik für Psychosomatische Medizin und Psychotherapie, Universitätsmedizin Göttingen
› Author Affiliations
Further Information

Publication History

eingereicht 04 March 2013

akzeptiert 04 May 2014

Publication Date:
16 July 2014 (online)

Zusammenfassung

Formen der autonomen und hämodynamischen Dysregulation sind mit einem erhöhten Morbiditäts- und Mortalitätsrisiko assoziiert und gelten als Begleiterscheinungen einiger psychosomatischer Störungsbilder. Unklar ist, ob stationäre Psychotherapie einen Effekt auf die physiologische Stressreaktivität hat und ob Zusammenhänge mit der Veränderung von psychometrischen Befunden bestehen. 77 Patienten wurden zu Beginn und zu Ende stationärer psychosomatischer Komplexbehandlung psychometrisch (PHQ, HADS) und psychophysiologisch (Herzrate, Blutdruck, Herzindex, kardiale Gesamtbelastung, kardiozirkulatorische Effizienz, Präejektionsperiode, LF-HRV und HF-HRV) unter verschiedenen Testbedingungen (Ruhe, Kopfrechnen, Angerrecall, Erholung) untersucht. Die Behandlung ging mit einer signifikanten Verbesserung der Symptome einher, während die physiologischen Aktivierungsparameter keine signifikanten Veränderungen zeigten. Ob weiterführende Maßnahmen im Anschluss an die Therapie auf längere Sicht einen günstigen physiologischen Effekt haben, bleibt zu untersuchen.

Abstract

Autonomic imbalance and exaggerated stress responses are associated with an increased risk of morbidity and mortality and have been associated with several psychosomatic disorders. Has in-patient psychotherapy any effect on autonomic regulation and mental stress reactivity? In 77 patients undergoing in-patient psychometric treatment psychometric examination and psychophysiological assessment of hemodynamic and autonomic parameters during rest and 2 mental stress tests was performed at the beginning and at the end of in-patient psychotherapy. Despite marked improvements in symptoms our short-term treatment for psychosomatic disorders did not affect autonomic and hemodynamic activation at rest or during stress testing. It remains to be investigated if increased physical activity and relaxation expected after improvement have beneficial physiological effects over longer time spans.

 
  • Literatur

  • 1 Rozanski A, Blumenthal JA, Kaplan J. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation 1999; 99: 2192-2217
  • 2 Gorman JM, Sloan RP. Heart rate variability in depressive and anxiety disorders. Am Heart J 2000; 140: 77-83
  • 3 Drago S, Bergerone S, Anselmino M et al. Depression in patients with acute myocardial infarction: influence on autonomic nervous system and prognostic role. Results of a five-year follow-up study. Int J Cardiol 2007; 115: 46-51
  • 4 Weber CS, Thayer JF, Rudat M et al. Low vagal tone is associated with impaired post stress recovery of cardiovascular, endocrine and immune markers. Eur J Appl Physiol 2010; 109: 201-211
  • 5 Tsuji H, Venditti FJ, Manders ES et al. Reduced heart rate variability and mortality risk in an elderly cohort: The Framingham Heart Study. Circulation 1994; 90: 878-883
  • 6 Tsuji H, Larson MG, Venditti jr FJ et al. Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation 1996; 94: 2850-2855
  • 7 Thayer JF, Lane RD. A model of neurovisceral integration ein emotion regulation and dysregulation. J Aff Dis 2000; 61: 201-216
  • 8 Chambers AS, Allen JJB. Cardiac vagal control, emotion, psychopathology and health. Biol Psychol 2007; 74: 113-115
  • 9 Kemp AH, Quintana DS, Gray MA et al. Impact of depression and antidepressant treatment on heart rate variability: A review and meta-analysis. Biol Psychiatry 2010;
  • 10 Ehrenthal J, Herrmann-Lingen C, Fey M, Schauenburg H. Altered cardiovascular adaptability in depressed patients without heart disease. World J Biol Psychiatry 2010; 11: 586-593
  • 11 Udupa K, Sathyaprabha TN, Thirthalli J et al. Alteration of cardiac autonomic functions in patients with major depression: a study using heart rate variability measures. J Affect Disord 2007; 100: 137-141
  • 12 Rottenberg J, Clift A, Bolden S et al. RSA fluctuation in major depressive disorder. Psychophysiology 2007; 44: 450-458
  • 13 Agelink MW, Boz C, Ullrich H et al. Relationship between major depression and heart rate variability. Clinical consequences and implications for antidepressive treatment. Psychiatry Res 2002; 111: 139-149
  • 14 Blechert J, Michael T, Grossman P et al. Autonomic and respiratory characteristics of posttraumatic stress disorder and panic disorder. Psychosom Med 2007; 69: 935-943
  • 15 Henje Blom E, Olsson EM, Salrachius E et al. Heart rate variability in adolescent females with anxiety disorders and major depressive disorder. Acta Paediatr 2010;
  • 16 Hoehn-Saric R, McLeod DR, Zimmerli WD. Psychophysiological response in panic disorder. Acta Psychiatr Scand 1991; 83: 4-11
  • 17 Kawachi I, Sparrow D, Vokonas PS et al. Decreased heart rate variability in men with phobic anxiety (data from Normative Aging Study). Am J Cardiol 1995; 75: 882-885
  • 18 Orr SP, Roth WT. Psychophysiological assessment: Clinical applications for PTSD. J Affect Disord 2000; 61: 225-240
  • 19 Cohen H, Kotler M, Matar MA et al. Analysis of heart rate variability in posttraumatic stress disorder patients in response to a trauma-related reminder. Biol Psychiatry 1998; 44: 1054-1059
  • 20 Sack M, Hopper JW, Lamprecht F. Low respiratory sinus arrhythmia and prolonged psychophysiological arousal in posttraumatic stress disorder: heart rate dynamics and individual differences in arousal regulation. Biol Psychiatry 2004; 55: 284-290
  • 21 Keary TA, Hughes JW, Palmieri PA. Women with posttraumatic stress disorder have a larger decrease in heart rate variability during stress tasks. Int J Psychophysiol 2009; 73: 257-264
  • 22 de Jonge P, Mangano D, Whooley MA. Differential association of cognitive and somatic depressive symptoms with heart rate variability in patients with stable coronary heart disease: Findings from the heart and soul study. Psychosom Med 2007; 69: 735-739
  • 23 Nishith P, Duntley SP, Domitrovich PP et al. Effect of cognitive behavioral therapy on heart rate variability during REM sleep in female rape victims with PTSD. J Trauma Stress 2003; 16: 247-250
  • 24 Mitani S, Fujita M, Sakamoto S et al. Effect of autogenic training on cardiac autonomic nervous activity in high-risk fire service workers for posttraumatic stress disorder. J Psysom Res 2006; 60: 439-444
  • 25 Carney RM, Freeland KE, Stein KP. Change in heart rate and heart rate variability during treatment for depression in patients with coronary heart disease. Psychosom Med 2000; 62: 639-647
  • 26 van Dixhoorn J, White A. Relaxation therapy for rehabilitation and prevention in ischaemic heart disease: A systematic review and meta-analysis. Eur J Cardiovasc Prev Rehabil 2005; 12: 193-202
  • 27 Neves Â, Alberto JA, Ribeiro F et al. The effect of cardiac rehabilitation with relaxation therapy on psychological, hemodynamic and hospital admission outcome variables. J Cardiopul Rehabil Prev 2009; 29: 304-309
  • 28 Joosen M, Sluiter J, Joling C et al. Evaluation of effects of a training programme for patients with prolonged fatigue on physiological parameters and fatigue complaints. Int J Occup Med Environ Health 2008; 21: 237-246
  • 29 Löwe B, Spitzer RL, Zipfel S et al. PHQ-D – Gesundheitsfragebogen für Patienten. Manual – Komplettversion und Kurzform. Karlsruhe: Pfizer GmbH; 2001
  • 30 Herrmann C, Buss U, Snaith RP. HADS-D. Hospital Anxiety and Depression Scale – Deutsche Version. Ein Fragebogen zur Erfassung von Angst und Depressivität in der somatischen Medizin; Testdokumentation und Handanweisung. Bern: Hans-Huber-Verlag; 1995
  • 31 Gräfe K, Zipfel S, Herzog W et al. Screening psychischer Störungen mit dem „Gesundheitsfragebogen für Patienten (PHQ-D)“. Diagnostica 2004; 50: 171-181
  • 32 Löwe B, Spitzer RL, Gräfe K et al. Comparative validity of three screening questionnaires for DSM-IV depressive disorders and physicians’ diagnoses. J Affect Disord 2004; 78: 131-140
  • 33 Kroenke K, Spitzer RL, Williams JBW. The PHQ-15: Validity of a New Measure for Evaluating the Severity of Somatic Symptoms. Psychosom Med 2002; 64: 258-266
  • 34 Fortin J et al. Evaluation of the Task-Force-Monitor. “Tenth european meeting on hypertension” European Society of Hypertension, Göteborg (Sweden) 2000
  • 35 Fortin J, Habenbacher W, Heller A et al. Non-invasive beat-to-beat cardiac output monitoring by an improved method of transthoracic bioimpedance measurement. Comput Biol Med 2006; 36: 1185-1203
  • 36 Ironson G, Taylor CB, Boltwood M et al. Effects of anger on left ventricular ejection fraction in coronary artery disease. Am J Cardiol 1992; 70: 281-285
  • 37 Strauß B, Burgmeister-Lohse M. Evaluation einer stationären Langzeitgruppenpsychotherapie. Psychother Psych Med 1994; 43: 82-92
  • 38 Lipsey MW, Wilson DB. The efficacy of psychological, educational and behavioral treatment. Confirmation from meta-analysis. Am J Psy 1993; 48: 1181-1209
  • 39 Keller W, Schneider W. Veränderungen interpersonaler Probleme im Verlauf ambulanter und stationärer Gruppenpsychotherapie. Gruppenpsychotherapie, Gruppendynamik 1993; 29: 308-323
  • 40 Nishith P, Duntley SP, Domitrovich PP et al. Effect of cognitive behavioral therapy on heart rate variability during REM sleep in female rape victims with PTSD. J Trauma Stress 2003; 16: 247-250
  • 41 Mitani S, Fujita M, Sakamoto S et al. Effect of autogenic training on cardiac autonomic nervous activity in high-risk fire service workers for posttraumatic stress disorder. J Psysom Res 2006; 60: 439-444
  • 42 Sack M, Lempa W, Steinmetz A et al. Alterations in autonomic tone during trauma exposure using movement desensitization and processing (EMDR) – Results of a preliminary investigation. J Anxiety Disord 2008; 22: 1264-1271
  • 43 Glassman AH, o’Connor CM, Califf RM et al. Sertraline treatment of major depression in patients with akute MI or unstable angina. JAMA 2002; 288: 701-709
  • 44 Kessler RC, Stang P, Wittchen HU et al. Lifetime panic-depression ­comorbidity in the National Comorbidity Survey. Arch Gen Psychiatry 1998; 55: 801-811
  • 45 Wittchen HU. Der Langzeitverlauf unbehandelter Angststörungen. Wie häufig sind Spontanremissionen?. Verhaltenstherapie 1991; 273-282
  • 46 Martin S, Kempf K, Dirk M et al. Kognitive Verhaltenstherapie bei Typ-2-Diabetes. Diabetologie 2009; 4: 1-4