Osteosarkom der Prostata nach Strahlentherapie

Zusammenfassung

Osteosarkome in der Prostata sind sehr seltene Tumore und werden meist Jahre nach Durchführung einer Strahlentherapie diagnostiziert. Wir berichten den Fall eines 74 Jahre alten Patienten, der wegen eines Adenokarzinoms der Prostata eine Strahlentherapie und komplette Androgenblockade erhalten hatte. Der Patient kam wegen Harnverhaltung ins Krankenhaus und erhielt eine palliative transurethrale Resektion der Prostata. Der histopathologische Befund zeigte eine Infiltration der Prostata mit niedrig differenziertem Osteosarkom G3. Wegen der Begleiterkrankungen wurde auf die Durchführung einer Chemotherapie verzichtet. Der Patient verstarb einige Monate später in metastasiertem Tumorstadium. Zum Schluss, Osteosarkome in der Prostata treten sehr selten als Folge einer Strahlentherapie bei Patienten mit Prostatakarzinom auf und sind durch eine äußerst schlechte Prognose charakterisiert.

Abstract

Osteosarcoma of the prostate is a rare fi nding. These tumours usually occur years after radiotherapy for prostate cancer. We report the case of a 74-year-old man with prostate cancer who had been treated with radiotherapy and androgen deprivation therapy. The man presented with urinary retention and his prostate was transurethrally resected. The histopathological investigation showed formations of a poorly diff erentiated osteosarcoma in the prostate. Because of serious comorbidities we decided to withhold chemotherapy considering its potential side effects. The man died a few months after the diagnosis of osteosarcoma in the prostate with the disease in a metastatic stage. In conclusion, osteosarcoma of the prostate is a rarely reported consequence of radiotherapy in patients with prostate cancer and is characterised by poor life expectancy.

Schlüsselwörter

Osteosarkom der Prostata - Prostatakarzinom - Strahlentherapie

Key words

osteosarcoma of the prostatel - prostate cancer - radiotherapy

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