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Drug Res (Stuttg) 2014; 64(09): 485-492
DOI: 10.1055/s-0033-1363251
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Non-carboxylic Analogues of Aryl Propionic Acid: Synthesis, Anti-inflammatory, Analgesic, Antipyretic and Ulcerogenic Potential

S. I. Eissa
1   Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azher University, Nasr City,Cairo, Egypt
,
A. M. Farrag
1   Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azher University, Nasr City,Cairo, Egypt
,
A. A. A. Galeel
2   Researcher, Pharmacology Department, National Research Center, Dokki, Cairo, Egypt
› Author Affiliations
Further Information

Publication History

received 06 October 2013

accepted 25 November 2013

Publication Date:
20 January 2014 (online)

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Abstract

As a part of ongoing studies in developing new potent anti-inflammatory and analgesic agents, a series of novel 6-methoxy naphthalene derivatives was efficiently synthesized and characterized by spectral and elemental analyses. The newly synthesized compounds were evaluated for their anti-inflammatory activities using carrageenin-induced rat paw edema model, analgesic activities using acetic acid induced writhing model in mice and anti-pyretic activity using yeast induced hyperpyrexia method as well as ulcerogenic effects. Among the synthesized compounds, thiourea derivative (6a, e) exhibited higher anti-inflammatory activity than the standard drug naproxen in reduction of the rat paw edema (88.71, 89.77%) respectively. All of the non-carboxylic tested compounds were found to have promising anti-inflammatory, analgesic and antipyretic activity, while were devoid of any ulcerogenic effects.

Key words

naproxen - anti-inflammatory - analgesic - antipyretic - ulcer effect
 

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