Increased Gene Expression of Glucose Transporters in the Mouse Brain after Treatment with Fluoxetine and Pergolide

Abstract

Glucose transporters play key roles in the homeostatic control of brain functions. In the present study, we examined the effect of fluoxetine, a selective serotonin reuptake inhibitor, and pergolide, a dopamine D receptor agonist, on the gene expression levels of glucose transporters in the mouse brain. mRNAs for 8 sodium-independent glucose transporters (GLUTs), other than GLUT4 and GLUT9, and sodium-dependent glucose transporter 1 (SGLT1) were confirmed to be expressed in brain tissue. Fluoxetine and pergolide significantly increased the expression levels of mRNAs for GLUT1 and GLUT10 in the brain. Furthermore, the expression of GLUT6 in tissue was increased by administering pergolide to mice. On the other hand, fluoxetine and pergolide had no effect on the expression levels of mRNAs for the other GLUTs and SGLT1. Therefore, we concluded that the gene expression of several GLUT isoforms in the mouse brain was affected by the treatment with fluoxetine and pergolide.

• References

• 1 Zhao F, Keating AF. Curr Genom 2007; 8: 113-128
• 2 Wright EM, Turk EM. Pflugers Arch 2004; 447: 510-518
• 3 Augustin R. IUBMB Life 2010; 62: 315-333
• 4 Nagai K, Konishi H. Fundam Clin Pharmacol DOI: doi: 10.1111/fcp.12011. (Epub ahead of print)
• 5 Boison D. Drug News Project 2007; 20: 607-611
• 6 Nagai K, Nagasawa K, Fujimoto S. Biochem Biophys Res Commun 2005; 334: 1343-1350
• 7 Muneer APM, Alikunju S, Szlachetka AM et al. Physiol Pathophysiol Pharmacol 2011; 3: 48-56
• 8 Turner DA, Adamson DC. J Neuropathol Exp Neurol 2011; 70: 167-176
• 9 Rudlowski C, Becker AJ, Schroder W et al. Clin Pathol 2003; 120: 691-698
• 10 Coucke PJ, Willaert JE, Wessels MW et al. Nat Genet 2006; 38: 452-457