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Drug Res (Stuttg) 2014; 64(7): 353-357
DOI: 10.1055/s-0033-1358704
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Evaluation of Serum Lipid Profile in Patients with Hypertension Living in a Coastal Region of Bangladesh

M. S. Sarwar
1   Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh
,
T. Adnan
1   Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh
,
M. D. Hossain
1   Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh
,
S. M. N. Uddin
1   Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh
,
M. S. Hossain
1   Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh
,
S. M. E. Al Baker
2   Department of Cardiology, Laksham Upazilla Health Complex, Comilla, Bangladesh
,
M. N. Uddin
3   Department of Applied Mathematics, Noakhali Science and Technology University, Noakhali, Bangladesh
,
M. S. Islam
1   Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh
› Author Affiliations
Further Information

Publication History

received 12 August 2013

accepted 16 October 2013

Publication Date:
13 November 2013 (online)

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Abstract

Serum lipid levels are greatly controlled by genetic and environmental factors. When investigating the relationship between lipid disturbances and hypertension it is necessary to use local data on blood lipid profile in each region. Unfortunately, there is no literature reporting the lipid profile in hypertensive patients in coastal region of Bangladesh. The present study was conducted as a case-control study with 100 hypertensive patients as cases and equal number of normotensive individuals as controls. Socio-demographic, anthropometric and clinical data of both patients and controls were collected. Serum lipid parameters were analyzed biochemically. Independent sample t-test, Chi-Square test and Pearson’s correlation test were done for the statistical analysis using the statistical software package SPSS. Our study found that serum total cholesterol (TC), triglyceride (TG), LDL, VLDL, TC/HDL, LDL/HDL were significantly higher (p<0.05) whereas the level of HDL cholesterol was significantly lower in hypertensive patients as compared to control subjects (p<0.05). Pearson’s correlation analysis reveals that HDL cholesterol was inversely correlated with systolic and diastolic blood pressure in both patient and control groups. But serum TC, TG, LDL and HDL cholesterol were directly correlated with systolic and diastolic blood pressure in both groups. This study explored that hypertensive patients have higher level of TC, TG, LDL and VLDL cholesterol but lower level of HDL cholesterol than the normotensive subjects. Routine investigation of lipid profile in hypertensive patients may help to prevent further aggravation and risks of coronary artery diseases.

Key words

hypertension - lipid profile - total cholesterol - triglyceride - HDL cholesterol - LDL cholesterol
 

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