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Exp Clin Endocrinol Diabetes 2014; 122(1): 31-34
DOI: 10.1055/s-0033-1358483
Article
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Risk factors of Charcot Neuroarthropathy Development in Patients with Type 2 Diabetes

P. Nehring
1   Gastroenterology and Metabolic Diseases Department, Medical University of Warsaw, Poland
,
B. Mrozikiewicz-Rakowska
1   Gastroenterology and Metabolic Diseases Department, Medical University of Warsaw, Poland
,
P. Maroszek
1   Gastroenterology and Metabolic Diseases Department, Medical University of Warsaw, Poland
,
A. Sobczyk-Kopcioł
2   Department of General Biology and Parasitology, Medical University of Warsaw, Poland
,
M. Krzyżewska
1   Gastroenterology and Metabolic Diseases Department, Medical University of Warsaw, Poland
,
R. Płoski
3   Department of Medical Genetic, Medical University of Warsaw, Poland
,
W. Karnafel
1   Gastroenterology and Metabolic Diseases Department, Medical University of Warsaw, Poland
› Author Affiliations
Further Information

Publication History

received 22 May 2013
first decision 19 August 2013

accepted 02 October 2013

Publication Date:
07 November 2013 (online)

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Abstract

Aim:

Charcot neuroarthropathy is a very rare form of diabetic foot syndrome occurring among others in patients with diabetes mellitus. Charcot neuroarthropathy leads to bone tissue destruction and may result in foot amputation. The aim of the study was to identify risk factors of Charcot neuroarthropathy occurrence in patients with diabetic foot and type 2 diabetes.

Materials:

The study included 144 patients with type 2 diabetes; 33 with Charcot neuroarthropathy and 111 with diabetic foot of neuropathic origin without neuroarthropathy. The study was perform in Gastroenterology and Metabolic Diseases Department, Medical University of Warsaw, Poland.

Results:

The regression analysis showed that Charcot neuroarthropathy occurrence risk factors were: male gender (OR=4.94, 95% CI:1.63–15.03, p=0.003), age (OR=0.92, 95% CI:0.87–0.96, p=0.0001), diabetic foot duration (OR=1.19, 95% CI:1.08–1.32, p=0.00002) and height (OR=1.078, 95% CI:1.019–1.140, p=0.007). A positive effect on Charcot neuroarthropathy presence was exerted by body weight (OR=1.027, 95% CI:1.003–1.051, p=0.03) and hips circumference (OR=1.034, 95% CI:0.997–1.072, p=0.04).

Conclusions:

The existence of the specific factors influencing Charcot neuroarthropathy development may result in earlier identification of patients at risk of its development. There is a necessity to take special care for patients prone to develop Charcot neuroarthropathy in order to prevent its occurrence and severe complications.

Key words

neuropathy - obesity - peripheral arterial disease
 

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