Synlett 2014; 25(07): 905-910
DOI: 10.1055/s-0033-1340621
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© Georg Thieme Verlag Stuttgart · New York

Metal-Free-Catalyzed Intramolecular Carbocyanation of Activated Alkenes: New Entry To Access Functionalized Nitriles Containing Quaternary Carbon Centers

Zhe Zhuang
Department of Organic Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. of China   Fax: +86(431)85153812   Email: wliao@jlu.edu.cn
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Wei-Wei Liao*
Department of Organic Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. of China   Fax: +86(431)85153812   Email: wliao@jlu.edu.cn
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Further Information

Publication History

Received: 17 November 2013

Accepted after revision: 12 December 2013

Publication Date:
05 February 2014 (online)


Abstract

Intramolecular carbocyanation reaction of alkenes has emerged as a powerful tool for preparing functionalized nitriles. In contrast to transition-metal-catalyzed processes, we have recently developed a metal-free carbocyanation (alkenylcyanation and acylcyanation) approach to construct functionalized nitriles incorporating a quaternary carbon center. This article summarizes our recent exploratory studies in this field.