Synlett 2014; 25(4): 509-514
DOI: 10.1055/s-0033-1340551
letter
© Georg Thieme Verlag Stuttgart · New York

Studies on the Phthalidation of Heteroarenes: A Facile Preparation of 3-(Heteroaryl)phthalides via Triflic Acid Mediated Phthalidation

Meganathan Nandakumar
Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai-600 025, Tamil Nadu, India   Fax: +91(44)22352494   Email: mohanakrishnan@unom.ac.in   Email: mohan_67@hotmail.com
,
Elumalai Sankar
Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai-600 025, Tamil Nadu, India   Fax: +91(44)22352494   Email: mohanakrishnan@unom.ac.in   Email: mohan_67@hotmail.com
,
Arasambattu K. Mohanakrishnan*
Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai-600 025, Tamil Nadu, India   Fax: +91(44)22352494   Email: mohanakrishnan@unom.ac.in   Email: mohan_67@hotmail.com
› Author Affiliations
Further Information

Publication History

Received: 19 October 2013

Accepted after revision: 09 December 2013

Publication Date:
31 January 2014 (online)


Abstract

A triflic acid mediated heteroarylation of phthalaldehydic acid in 1,2-dichloroethane at reflux temperature leads to the formation of 3-heteroarylphthalides. This method for the phthalidation of heteroarenes can be utilized for the successful preparation of mono-, bis- and tris-heteroarylphthalides.

Supporting Information

 
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