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Synfacts 2014; 10(1): 0107
DOI: 10.1055/s-0033-1340378
DOI: 10.1055/s-0033-1340378
Polymer-Supported Synthesis
Preparation of Nitrones Using γ-Fe2O3@SiO2-H3PW12O40
Further Information
Publication History
Publication Date:
13 December 2013 (online)
![](https://www.thieme-connect.de/media/synfacts/201401/i_y131_s1_10-1055_s-0033-1340378.gif)
Significance
The oxidation of secondary amines by superparamagnetic tungstophosphoric acid supported on silica-encapsulated γ-Fe2O3 (γ-Fe2O3@SiO2-H3PW12O40) was carried out with an aqueous hydrogen peroxide as oxidant to give the corresponding nitrones 1a–h in up to 90% yield.
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Comment
The γ-Fe2O3@SiO2-H3PW12O40 nanoparticles were readily recovered by an external magnet and reused three times without significant loss of catalytic activity (1st reuse: 1a 85% yield, 3rd reuse: 1a 80% yield). The authors previously reported the preparation of γ-Fe2O3@SiO2-H3PW12O40 and its application to the synthesis of formamidines (J. Mol. Struct. 2012, 1027, 156).
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![](https://www.thieme-connect.de/media/synfacts/201401/i_y131_s1_10-1055_s-0033-1340378.gif)