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Synlett 2013; 24(18): 2407-2410
DOI: 10.1055/s-0033-1339670
DOI: 10.1055/s-0033-1339670
letter
Insight into β-Hairpin Stability: Interstrand Hydrogen Bonding
Further Information
Publication History
Received: 16 July 2013
Accepted: 02 August 2013
Publication Date:
28 August 2013 (online)
Abstract
For evaluation of the role of interstrand hydrogen bonding for β-hairpin stability, two cyclic peptides differing only in side chain hydroxy-to-methyl substitution were designed and synthesized on solid phase following the Fmoc–t-Bu–Trt protection strategy. Subsequent to cyclization in solution, combined computational and experimental ensemble analysis revealed higher conformational stability of the peptide capable of interstrand hydrogen bonding.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
-
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