Synthetic Developments on the Indolizidine Alkaloid, Harmicine

Abstract

Indolizidine alkaloids are widespread in Nature and display a wide spectrum of biological activity. Harmicine, as an example of an indolizidine alkaloid, shows antileishmanial and antinociceptive activity, and is an interesting target for synthetic organic chemists. This article provides a comprehensive review of the synthetic routes toward harmicine since its isolation in 1997.

1 Introduction

2 Synthetic Approaches

3 Conclusions

Key words

harmicine - β-carboline - indolizidines - alkaloids - antileishmania - antinociceptive - natural products

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