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Semin Liver Dis 2013; 33(01): 079-088
DOI: 10.1055/s-0033-1338116
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Development of the Hepatitis E Vaccine: From Bench to Field

Jun Zhang
1   National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China
,
James WaiKuo Shih
1   National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China
,
Ting Wu
1   National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China
,
Shao-Wei Li
1   National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China
,
Ning-Shao Xia Prof.
1   National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, People's Republic of China
› Author Affiliations
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Publication History

Publication Date:
05 April 2013 (online)

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Abstract

Along with the improvement of diagnostic techniques, hepatitis E has attracted increasing awareness in recent years. Hepatitis E virus infection leads to high mortality in pregnant women and patients with underlying liver disease. Several hepatitis E vaccine candidates have been designed and have proved their efficacy in animal models; two candidates have successfully undergone clinical trials. Having proved safe and effective in a large phase III trials, an Escherichia coli expressed particulate protein, HEV 239, has been registered in China and is now available for use in China.

Keywords

hepatitis E virus - HEV - antigenic determinants - vaccine - immunogenicity - vaccine efficacy
 

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