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Arzneimittelforschung 2012; 62(12): 590-594
DOI: 10.1055/s-0032-1327610
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Antimicrobial and Cytotoxicity Potential of Acetamido, Amino and Nitrochalcones

T. C. Tristão
1   Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Itajaí, Brazil
,
F. Campos-Buzzi
1   Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Itajaí, Brazil
2   Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí, Itajaí, Brazil
,
R. Corrêa
1   Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Itajaí, Brazil
2   Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí, Itajaí, Brazil
,
R.C B. Cruz
2   Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí, Itajaí, Brazil
,
V. Cechinel Filho
1   Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Itajaí, Brazil
2   Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí, Itajaí, Brazil
,
A. Bella Cruz
1   Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Itajaí, Brazil
2   Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí, Itajaí, Brazil
› Author Affiliations
Further Information

Publication History

received 10 April 2012

accepted 18 September 2012

Publication Date:
19 October 2012 (online)

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Abstract

Background:

Chalcones constitute one of the major classes of natural products belonging to the flavonoid family, and they have been reported as having a range of important therapeutic activities, including some chalcones are effective as antimicrobial agents. Currently, the search for new structures with antimicrobial activity has been intensified due to the emergence of many strains resistant to antibiotics currently used to treat infectious diseases.

Method:

3 chalcone series (amino, acetamido and nitrochalcones) were prepared (23 compounds) and evaluated for their antimicrobial and cytotoxic potential. The effects of substituents on their respective activities also was evaluated.

Results & Conclusion:

The results showed that 4 aminochalcones (2, 4, 8, 9), 3 acetoamidochalcones (10, 14, 18) and 3 nitrochalcones (20, 22, 23), exhibited antifungal effects. The aminochalcones were more toxic than the acetamidochalcones, while the nitrochalcones did not present any toxic effect. It was verified that there seems to be structure-activity correlation in some electron-donating and withdrawing substituents groups in rings A and B of the synthetized chalcone analogues and its antifungal and cytotoxic activity.

Key words

antibacterial - antifungal - Artemia salina - QSAR - chalcone
 

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