Direct Oxidative C–H Arylation of Benzoxazoles with Arylsulfonyl Hydrazides Promoted by Palladium Complexes

Abstract

This study describes a direct oxidative C-2 arylation of benzoxazoles using arylsulfonyl hydrazides as the aryl sources. A simple catalyst system [Pd(OAc)₂ and Ph₃P] allows the reactions to proceed smoothly under oxidative reaction conditions. Other ­heteroarenes such as caffeine and benzothiazole are also applicable substrates. Notably, this catalytic system tolerates halogen substituents which provides a useful complement to the current cross-­coupling reactions which use aryl halides.

Key words

palladium - arylation - arylsulfonyl chlorides - phosphine - benzoxazoles

• References


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