Incomptines C and D, Two Heliangolides from Decachaeta incompta and Their Antiprotozoal Activity

Elihú Bautista; Fernando Calzada; Lilian Yepez-Mulia; Marco Chavez-Soto; Alfredo Ortega

doi:10.1055/s-0032-1315255

Planta Medica, Table of Contents

Planta Med 2012; 78(15): 1698-1701
DOI: 10.1055/s-0032-1315255

Natural Product Chemistry

Letters

Georg Thieme Verlag KG Stuttgart · New York

Incomptines C and D, Two Heliangolides from Decachaeta incompta and Their Antiprotozoal Activity

Elihú Bautista

¹Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, México City, México

,

Fernando Calzada

²Unidad de Investigación Médica en Farmacología. UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México City, México

,

Lilian Yepez-Mulia

³Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, México City, México

,

Marco Chavez-Soto

²Unidad de Investigación Médica en Farmacología. UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México City, México

,

Alfredo Ortega

¹Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, México City, México

› Author Affiliations

Abstract

Two new heliangolides, incomptines C (3) and D (4), were isolated from the leaves of Decachaeta incompta. The structures were established by spectroscopic methods and confirmed by X-ray crystallography. The antiprotozoal activity of incomptines C and D was evaluated. Additionally, the chromatographic profile of the leaves and roots extracts were compared to identify incomptines A–D (1–4) in each extract.

Key words

Asteraceae - Decachaeta incompta - Giardia lamblia - Entamoeba histolytica - heliangolides - antiprotozoal activity

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References

References
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