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Horm Metab Res 2012; 44(06): 436-441
DOI: 10.1055/s-0031-1301301
Original Basic
© Georg Thieme Verlag KG Stuttgart · New York

Reversed Glucose and Fatty Acids Transporter Expression in Human Endometrial Cancer

P. Knapp
1   Department of Gynecology, Medical University of Białystok, Białystok, Poland
,
A. Chabowski
2   Department of Physiology, Medical University of Białystok, Białystok, Poland
,
D. Harasiuk
2   Department of Physiology, Medical University of Białystok, Białystok, Poland
,
J. Górski
2   Department of Physiology, Medical University of Białystok, Białystok, Poland
› Author Affiliations
Further Information

Publication History

received 30 June 2011

accepted 22 December 2011

Publication Date:
20 February 2012 (online)

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Abstract

Cancer cells exhibit accelerated rates of metabolism favoring glucose over fatty acid (FA) utilization. For both energy substrates, protein-mediated transport plays an essential role in facilitating glucose or FA movement across plasma membrane into the cells. Scarce data exist regarding the expression of glucose and/or FA transporter in cancer tissue. Therefore, we examined glucose (GLUT-1, GLUT-3, GLUT-4) and FA (FAT/CD36, FABPpm, FATP-1) transporter expressions at the protein and post-transcript (mRNA) levels in 35 endometrial carcinomas (G1, type endometrioid, FIGO I) and compared them with normal endometrial mucosa (n=10). Endometrial cancer tissue had significantly greater protein expression of GLUT-1, GLUT-3, and GLUT-4 (+ 40%; + 20%; + 24%; p<0.05, respectively) and, conversely, lower fatty acid (FAT/CD36 and FATP-1) transporter expression ( − 25%; p<0.05 and  − 15%, p>0.05 respectively). Interestingly, mRNA content closely mirrors the changes, but only for glucose transporters and not fatty acid transporters. These results suggest the presence of metabolic switch of energy utilization in endometrial cancers favoring glucose consumption as the major source of energy.

Key words

FAT/CD36 - FABPpm - GLUT-1 - GLUT-3 - GLUT-4 - endometrial cancer
 

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