Arzneimittelforschung 2012; 62(04): 167-175
DOI: 10.1055/s-0031-1299744
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Synthesis of Cyclopentapyridine and Thienopyridine Derivatives as Potential Calcium Channel Modulators

M. G. Gündüz
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
,
C. Şafak
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
,
B. Kaygısız
2   Department of Pharmacology, Faculty of Medicine, Osman Gazi University, Eskişehir, Turkey
,
B. Ç. Koşar
2   Department of Pharmacology, Faculty of Medicine, Osman Gazi University, Eskişehir, Turkey
,
R. Şimşek
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
,
K. Erol
2   Department of Pharmacology, Faculty of Medicine, Osman Gazi University, Eskişehir, Turkey
,
A. Linden
3   Institute of Organic Chemistry, University of Zurich Zurich, Switzerland
› Author Affiliations
Further Information

Publication History

received 02 December 2011

accepted 19 December 2011

Publication Date:
27 January 2012 (online)

Abstract

In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1–21) or tetrahydrothiophene-1,1-dioxide ring (22–42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.

 
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