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Planta Med 2012; 78(10): 1015-1019
DOI: 10.1055/s-0031-1298623
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

Polyphenolic Acetylcholinesterase Inhibitors from Hopea chinensis

Tong Yan
1   Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Ting Wang
1   Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Wei Wei
1   Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Nan Jiang
2   School of Pharmacy, Nanjing Medical University, Nanjing, China
,
Yan Hua Qin
1   Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Ren Xiang Tan
1   Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Hui Ming Ge
1   Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
› Author Affiliations
Further Information

Publication History

received 02 December 2011
revised 17 April 2012

accepted 07 May 2012

Publication Date:
24 May 2012 (online)

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Abstract

Bioassay-guided investigation of the stem bark of Hopea chinensis led to the isolation of two new polyphenols, hopeachinols C (1) and D (2), together with ten known compounds (3–12). Compounds 1 and 2 were determined by extensive analysis of spectroscopic data and computational methods. All of these phytochemicals were tested for acetylcholinesterase inhibitory activity, and five resveratrol-derived compounds (1 and 7–10) exhibited significant activity with their IC50 values ranging from 4.81 to 11.71 µM.

Key words

Hopea chinensis Hand.-Mazz. - Dipterocarpaceae - acetylcholinesterase inhibitor - polyphenol - structure elucidation

Supporting Information

 

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