Planta Med 2012; 78(7): 737-739
DOI: 10.1055/s-0031-1298367
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Drimane-type Sesquiterpenes with a Dioxabicyclooctane Skeleton from the Fruiting Bodies of Nigrofomes melanoporus and Their Cytotoxicity

Hsiu-Hui Chan1 [*] , Shin-Hun Juang2 , 3 [*] , Tran Dinh Thang4 [*] , Min-Yu Chen3 , Ping-Chung Kuo5 , Mei-Lin Yang6 , Nguyen Thi Ngan4 , Nguyen Ngoc Linh4 , Tian-Shung Wu1 , 6 , 7
  • 1Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan
  • 2Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
  • 3Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan
  • 4Department of Chemistry, Vinh University, Vinh City, Nghean province, Vietnam
  • 5Department of Biotechnology, National Formosa University, Yunlin, Taiwan
  • 6Department of Chemistry, National Cheng Kung University, Tainan, Taiwan
  • 7Department of Pharmacy, China Medical University, Taichung, Taiwan
Further Information

Publication History

received September 9, 2011 revised February 10, 2012

accepted February 17, 2012

Publication Date:
21 March 2012 (online)

Abstract

Two new drimane-type compounds, nigrofomins A (1) and B (2), possessing a rare dioxabicyclooctane moiety, were purified from the fruiting bodies of Nigrofomes melanoporus. Their structures were determined using 1D-, 2D-NMR and HR-ESI-MS spectroscopic analyses. In addition, 1 was established by X-ray crystallographic studies. Both nigrofomins A (1) and B (2) exhibited cytotoxicity on acute T-cell leukemia (Jurkat), human nasopharyngeal carcinoma (NPC-TW01), and lung cancer (NCI-H661) cells with IC50 values in the range of 99.44–246.32 µM. Furthermore, the effects of 1 and 2 on cell-cycle progression of Jurkat cells displayed a concentration-dependent accumulation in the G0/G1 phase.

Supporting Information

References

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1 These authors provided equal contributions to this work.

Prof. Tian-Shung Wu

Department of Chemistry
National Cheng Kung University

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