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Planta Med 2012; 78(5): 465-471
DOI: 10.1055/s-0031-1298147
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Sesquiterpene Lactones from Inula hookeri

Xiang-Rong Cheng1 , Wei-Wei Li1 , Jie Ren1 , Qi Zeng1 , Shou-De Zhang1 , Yun-Heng Shen2 , Shi-Kai Yan1 , Ji Ye2 , Hui-Zi Jin1 , Wei-Dong Zhang1 , 2
  • 1School of Pharmacy, Shanghai Jiao Tong University, Shanghai, PR China
  • 2School of Pharmacy, Second Military Medical University, Shanghai, PR China
Further Information

Publication History

received October 5, 2011 revised Nov. 16, 2011

accepted Dec. 12, 2011

Publication Date:
10 January 2012 (online)

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Abstract

Four new sesquiterpene lactones, (1S,5R,6S,7S,8R,9R,10S,11S)-6-acetoxy-9-hydroxy-4-oxo-pseudoguai-2(3)-en-12,8-olide (1), (1S,2R,5R,6S,7R,8S,10R)-6-acetoxy-2-ethoxy-4-oxo-pseudoguai-11(13)-en-12,8-olide (2), (1S,2R,5R,6S,7R,8S,10R)-6-acetoxy-2-hydroxy-4-oxo-pseudoguai-11(13)-en-12,8-olide (3), and 14-acetoxy-1β,5α,7αH-4β-hydroxy-guai-9(10),11(13)-dien-12,8α-olide (4), along with 26 known sesquiterpene lactones, were isolated from the whole plants of Inula hookeri C. B. Clarke. Their structures were established based on spectroscopic methods including HRESIMS, 1D and 2D NMR, and CD techniques. All compounds were evaluated for their cytotoxic activities against HepG2, HeLa, PC-3, and MGC-803 cell lines by CCK-8 assay. Some of the isolates, especiallly pseudoguaianolides and guaianolides, exhibited significant cytotoxicities against these four examined cell lines.

Key words

Inula hookeri - Compositae - sesquiterpene lactones - cytotoxicity - CCK-8 assay

Supporting Information

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Dr. Hui-Zi Jin
Wei-Dong Zhang

School of Pharmacy
Shanghai Jiao Tong University

Shanghai Dongchuan Rd 800

Shanghai 200240

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