Arzneimittelforschung 2008; 58(3): 131-135
DOI: 10.1055/s-0031-1296482
Antidiabetics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Antidiabetic Activity of Some New Thiazolyl-2,4-thiazolidine-diones

Oya Bozdağ-Dündar
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandoğan, Ankara, Turkey
,
Arzu Menteşe
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandoğan, Ankara, Turkey
,
Eugen J Verspohl
2   Department of Pharmacology, Institute of Medicinal Chemistry, Münster University, Münster, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
15 December 2011 (online)

Summary

In this study, a series of thiazolyl-2,4-thi-azolidinediones (VIa-f, VIIa-f and VIIIa-f) was prepared by Knoevenagel reaction of substituted phenacyl-2,4-thiazolidine-diones (IVa-f)/substituted benzyl-2,4-thi-azolidinediones (Va-f) with chlorothiaz-olecarbaldehydes (II, III). The prepared compounds were tested for their insuli-notropic activities in INS-1 cells. A significant insulinotropic effect was seen with compounds VIa, VIb, VIe, VIIa, VIIb and VIIId. Introducing a 2-[(phenylethyl)thio] group into the thiazole ring increased the biological effect, whereas N02 groups in phenylacyl or benzyl groups diminished the effects.

 
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