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Synlett 2012; 23(10): 1529-1533
DOI: 10.1055/s-0031-1291042
DOI: 10.1055/s-0031-1291042
letter
Potassium tert-Butoxide Promoted Cycloaddition Reaction for the Synthesis of 1,5-Disubstituted 1,2,3-Triazoles from Aromatic Azides and Trimethylsilyl-Protected Alkynes
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Publikationsverlauf
Received: 03. Januar 2012
Accepted after revision: 25. März 2012
Publikationsdatum:
25. Mai 2012 (online)


Abstract
The cycloaddition reaction of aromatic azides and trimethylsilyl alkynes upon treatment with desilylating reagents was investigated. In the process, the use of t-BuOK in wet DMF generated 1,5-disubstituted 1,2,3-triazoles regioselectively in moderate to good yields at ambient temperature.
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- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
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