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Synlett 2012; 23(13): 1901-1906
DOI: 10.1055/s-0031-129043
DOI: 10.1055/s-0031-129043
letter
[3+2] Cycloaddition of Masked o-Benzoquinones with Azomethine Ylides
Further Information
Publication History
Received: 02 May 2012
Accepted after revision: 18 June 2012
Publication Date:
16 July 2012 (online)
Abstract
A simple and efficient access to highly functionalized isoindolone derivatives via a [3+2] cycloaddition process between in situ generated azomethine ylides with various stable (isolable) masked o-benzoquinones is described. This approach allows a rapid and general synthesis of isoindolones with substituents to further manipulate and elaborate the structural complexity.
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