Synthesis of Thymidine Dimers from 5′-O-Aminothymidine

Abstract

The synthesis of modified oligonucleotides is of great importance for various therapeutic and diagnostic applications. The facile secondary structure formation of N-oxyamide-linked peptide analogues and the high nucleophilicity of the aminooxy function prompted us to prepare O-amino nucleoside derived dinucleosides. Herein, the efficient synthesis of three novel thymidine dimers with N-oxyamide, oxime and oxyamine linkages via a convergent approach from a common 5′-O-aminothymidine is reported.

Key words

dinucleosides - O-amino nucleoside - thymidine - N-oxyamide - oxime - oxyamine

• References

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