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Spectral and Analytical
Data of
8a
[α]D
²5 -103.5
(c 2.0, CHCl3). IR (neat): ν = 3433,
2934, 1415, 1153, 1097, 1034, 925, 850. cm-¹. ¹H
NMR (300 MHz, CDCl3): δ = 5.72
(m, 1 H, CH=CH2),
5.20 (m, 2 H, CH=CH
2),
4.58 (ABq, J = 37.8,
6.6 Hz, 2 H, OCH
2OCH3), 4.28
(m, 1 H, CHOCH2OCH3),
4.04 (m, 1 H, CH3CHO), 3.39
(s, 3 H, OCH2OCH
3),
2.60 (br s,1 H, OH), 1.71-1.56 (m, 2 H, CHCH
2CH), 1.19 (d, J = 6.2 Hz,
3 H, CH3) ppm. ¹³C NMR (75
MHz, CDCl3): δ = 137.6,
116.8, 94.2, 72.3, 64.2, 55.6, 43.9, 23.3 ppm. ESI-MS: m/z = 183
C8H16O3Na [M + Na]+.
14
Spectral and Analytical
Data of 8b
[α]D
²5 +6.1
(c 1.0, CHCl3). IR (neat):
3432, 2933, 1644, 1153, 1098, 1034, 925, 767 cm-¹. ¹H
NMR (300 MHz, CDCl3): δ = 5.67
(m, 1 H, CH=CH2),
5.28-5.16 (m, 2 H, CH=CH
2),
4.59 (ABq, J = 59.0,
6.8 Hz, 2 H, OCH
2OCH3), 4.24
(m, 1 H, CH3CHOSi), 3.98 (m,
1 H, CHOCH2OCH3), 3.39
(s, 3 H, CH2OCH
3),
1.78-1.57 (m, 2 H, CHCH
2CH), 1.18
(d, J = 6.0
Hz, 3 H, CH3) ppm. ¹³C NMR
(75 MHz, CDCl3): δ = 137.6,
116.7, 94.1, 75.1, 66.6, 55.6, 43.9, 23.3 ppm. ESI-MS: m/z (C8H16O3Na) =183 [M + Na]+.
15
Mitsunobu O.
Synthesis
1981,
1
16
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Hanack M.
Chang LWK.
Imhoff MA.
Schleyer P.
Effenberger F.
Kurtz W.
Stang PJ.
Dueber TE.
J. Org. Chem.
1976,
41:
4099
17a
Luo F.-T.
Wang R.-T.
Tetrahedron
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1991,
32:
7703
17b
Dushin RG.
Danishefsky SJ.
J.
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1992,
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655
17c
Kamisuki S.
Takashi S.
Mizushina Y.
Hanashima S.
Kuramochi K.
Kobayashi S.
Sakaguchi K.
Nakata T.
Sugawara F.
Tetrahedron
2004,
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5695
18
Bhattacharjee A.
Sequil OR.
De Brabander JK.
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19
Spectral and Analytical
Data of
7a
[α]D
²7 -59.6
(c 1.1, CHCl3). IR (neat):
3417, 2929, 1731, 1647, 1607, 1576, 1315, 1255, 1162, 1030, 967,
697 cm-¹. ¹H NMR
(300 MHz, CDCl3): δ = 11.71
(br s, 1 H, ArOH), 7.41-7.27 (m, 5 H, ArH), 6.37 (d, J = 2.2 Hz,
1 H, ArH), 6.34 (d, J = 2.2
Hz, 1 H, ArH), 5.89 (m, 1 H, CH=CH2),
5.65 (m, 1 H, CH=CH2),
5.45-5.16 (m, 4 H, CH=CH
2,
CH=CH
2), 5.07-4.91
(s, 2 H, ArOCH2), 5.04 (s, 2 H), 4.64 (m, 1 H, CH3CHOC=O), 4.50 (dd, J = 6.7, 2.8
Hz, 1 H, CHOCH2OCH3),
4.10 (m, 1 H, ArCH2), 3.64 (m, 1 H, ArCH2),
3.34 (s, 3 H, OCH3), 1.88-1.80 (dd, J = 6.6, 1.5
Hz, 2 H, OCHCH
2CHO), 1.40
(d, J = 6.2
Hz, 3 H, CH3) ppm.
¹³C
NMR (75 MHz, CDCl3): δ = 170.8,
165.5, 163.0, 144.5, 137.4, 137.6, 137.3, 128.6, 128.1, 127.5, 117.8,
117.6, 115.6, 111.35, 100.1, 93.7, 73.7, 69.9, 69.5, 55.6, 42.0,
40.3, 20.6 ppm. ESI-HRMS: calcd for C25H30O6Na [M + Na]+: 449.1940;
found: 449.1922.
Spectral and Analytical
Data of 7b
[α]D
²7 -23.12
(c 1.2, CHCl3). IR (neat):
2934, 1646, 1610, 1575, 1452, 1315, 1255, 1162, 1030, 966, 918,
695 cm-¹. ¹H NMR
(300 MHz, CDCl3): δ = 11.72
(br s, 1 H, ArOH), 7.40-7.31 (m, 5 H, ArH), 6.44 (d, J = 2.4 Hz,
1 H, ArH), 6.34 (d, J = 2.2
Hz, 1 H, ArH), 5.91 (m, 1 H, CH=CH2),
5.66 (m, 1 H, CH=CH2),
5.34-5.16 (m, 4 H, CH=CH
2,
CH=CH
2), 5.07-4.91
(m, 2 H, ArOCH2), 5.04 (s, 2 H, OCH
2OCH3), 4.64
(m, 1 H, CH3CHOC=O),
4.45 (dd, J = 6.7,
2.8 Hz, 1 H), 4.11 (m, 1 H), 3.65 (m, 1 H) 3.34 (s, 3 H, OCH2OCH
3), 1.88-1.81 (dd, J = 8.3, 1.5
Hz, 2 H, OCHCH
2CHO), 1.41
(d, J = 6.2
Hz, 3 H, CH3) ppm. ¹³C NMR
(75 MHz, CDCl3): δ = 170.5,
164.8, 163.0, 143.6, 137.7, 137.2, 136.1, 128.5, 128.1, 127.4, 126.9,
117.5, 115.5, 108.7, 100.5, 93.6, 74.5, 69.8, 55.5, 42.1, 40.2,
20.1 ppm. ESI-HRMS: m/z calcd
for C25H30O6Na [M + Na]+:
449.1940; found: 449.1927.
20
Spectral and Analytical
Data of 1
Mp 144-145 ˚C. [α]D
²0 +8.6
(c 1.0, EtOH). IR (KBr): 3504, 3423,
3179, 2941, 1657, 1609, 1458, 1391, 1318, 1264, 1207, 1165 cm-¹. ¹H
NMR (500 MHz, acetone-d
6): δ = 11.02 (br
s, 1 H), 9.29 (br s, 1 H) 6.28 (d, J = 2.1
Hz, 1 H), 6.24 (d, J = 2.1
Hz, 1 H), 4.96 (m, 1 H), 3.83 (m, 1 H), 3.72 (s, 1 H), 3.23 (dt, J = 13.4,
7.2 Hz, 1 H), 2.56 (ddd, J = 13.4,
8.2, 6.0 Hz, 1 H), 2.09 (m, 1 H), 2.01 (m, 2 H), 1.78 (m, 1 H),
1.53 (m, 1 H), 1.44 (d, J = 6.2
Hz, 3 H), 1.30 (m, 1 H) ppm. ¹³C NMR
(75 MHz, acetone-d
6): δ = 171.9,
163.4, 163.1, 149.5, 111.9, 106.2, 101.7, 73.2, 72.0, 45.9, 37.5,
37.0, 27.1, 21.5.ppm. ESI-MS: m/z = 267
C14H18O5 [M + H]+.
ESI-HRMS: m/z calcd for C14H18O5 [M + H]+:
267.1227; found: 267.1255.
21
Spectral and Analytical
Data of 2
Mp 154-155 ˚C. [α]D
²5 +55.0
(c 1.1, EtOH). IR (KBr): 3455, 2926,
1653, 1457, 1319, 1262, 1204, 1163, 1102 cm-¹. ¹H NMR
(300 MHz, acetone-d
6): δ = 11.6
(br s, 1 H), 9.25 (br s, 1 H), 6.31 (d, J = 2.2
Hz, 1 H), 6.24 (d, J = 2.2
Hz, 1 H), 5.40 (m, 1 H), 4.22 (m, 1 H), 3.39 (ddd, J = 12.6,
4.3, 3.9 Hz, 1 H), 2.40 (m, 1 H), 2.16 (m, 1 H), 1.70-1.91
(m, 3 H), 1.50 (m, 1 H), 1.45 (d, J = 6.4
Hz, 3 H), 1.31 (m, 1 H) ppm. ¹³C NMR
(75 MHz, acetone-d
6): δ = 172.6,
167.6, 164.6, 150.1, 113.1, 106.2, 102.8, 71.4, 67.8, 43.9, 38.2,
37.2, 29.5, 21.2 ppm. ESI-MS: m/z = 267
C14H18O5 [M + H]+.
ESI-HRMS: m/z calcd for C14H18O5 [M + H]+:
267.1227; found: 267.1206.