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Synfacts 2011(12): 1373-1373  
DOI: 10.1055/s-0031-1289413
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Suzuki-Miyaura Reaction with NHC-Cu-Pd MOF Catalysts

Contributor(s):Yasuhiro Uozumi, Yoichi M. A. Yamada, Yoshinari Yuyama
G.-Q. Kong, X. Xu, C. Zou, C.-D. Wu*
Zhejiang University, Hangzhou, P. R. of China
Two Metal-Organic Frameworks Based on a Double Azolium Derivative: Post-Modification and Catalytic Activity
Chem. Commun.  2011,  47:  11005-11007  
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Publication History

Publication Date:
18 November 2011 (online)

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Key words

N-heterocyclic carbenes - palladium - cross-coupling

Significance

A metal-organic framework (MOF) catalyst 2 was prepared from dicarboxylic acid H2 LCl2 bearing two azolium components through the MOF formation with Cu(NO3)2˙3H2O followed by the modification with Pd(OAc)2. The Suzuki-Miyaura reaction of aryl halides and arylboronic acids was carried out with 2 (10 mol%) in toluene to give the corresponding biaryl products in 81-99% yield.

Comment

MOF catalyst 2 was recovered by filtration and reused five times without loss of catalytic activity. A catalyst prepared from H2 LCl2, CuCl2, and Pd(OAc)2, which has a different MOF structure, exhibited much lower catalytic activity (4-methoxybiphenyl: 43%) than 2, highlighting the important roles of the framework structures in determining the catalytic performance.

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