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Synfacts 2011(11): 1221-1221
DOI: 10.1055/s-0031-1289179
DOI: 10.1055/s-0031-1289179
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids
F. Berhal, Z. Wu, J.-P. Genêt, T. Ayad*, V. Ratovelomanana-Vidal*
Chimie ParisTech, France
Further Information
Publication History
Publication Date:
19 October 2011 (online)
Significance
The Rh-catalyzed 1,4-addition of arylboronic acids to unsaturated ketones is an important method for the enantioselective construction of C-C bonds. In this report, electron-deficient phosphine ligands were found to be particularly effective, tolerating a wide variety of substrates with excellent enantioselectivity.