Die Mitralklappenendokardiose

Die Mitralklappenendokardiose (engl.: chronic valvular degeneration; myxomatous mitral valve disease) ist die häufigste Herzerkrankung des Hundes. Sie ist durch eine progressive Degeneration des Bindegewebes der Mitralklappe gekennzeichnet. Lesen Sie hier über Pathogenese, Klinik sowie die aktuellen Therapieempfehlungen.

• Literatur

• 1 Araujo JP, Lourenco P, Rocha-Goncalves F, Ferreira A, Bettencourt P. Nutritional markers and prognosis in cardiac cachexia. Int J Cardiol 2011; 146: 359-363
• 2 Atkins C, Bonagura J, Ettinger S, Fox P, Gordon S, Haggstrom J et al Guidelines for the diagnosis and treatment of canine chronic valvular heart disease. J Vet Intern Med 2009; 23: 1142-1150
• 3 Atkins CE, Keene BW, Brown WA, Coats JR, Crawford MA, DeFrancesco TC et al Results of the veterinary enalapril trial to prove reduction in onset of heart failure in dogs chronically treated with enalapril alone for compensated, naturally occurring mitral valve insufficiency. J Am Vet Med Assoc 2007; 231: 1061-1069
• 4 Billman GE, Kang JX, Leaf A. Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs. Circulation 1999; 99: 2452-2457
• 5 Biscione F, Totteri A, Vita A De, Bianco F Lo, Altamura G. [Effect of omega-3 fatty acids on the prevention of atrial arrhythmias]. Ital Heart J Suppl 2005; 6: 53-59
• 6 Boswood A, Smith S, Patteson M. Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical mitral valve disease. Vet Rec 2011; 168: 222
• 7 Haggstrom J, Boswood A, O'Grady M, Jons O, Smith S, Swift S et al Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the QUEST study. J Vet Intern Med 2008; 22: 1124-1135
• 8 Kvart C, Haggstrom J, Pedersen HD, Hansson K, Eriksson A, Jarvinen AK et al Efficacy of enalapril for prevention of congestive heart failure in dogs with myxomatous valve disease and asymptomatic mitral regurgitation. J Vet Intern Med 2002; 16: 80-88
• 9 Madsen MB, Olsen LH, Haggstrom J, Hoglund K, Ljungvall I, Falk T et al Identification of 2 loci associated with development of myxomatous mitral valve disease in Cavalier King Charles Spaniels. J Hered 2011; 102 (Suppl. 01) S62-S67
• 10 Mow T, Pedersen HD. Increased endothelin-receptor density in myxomatous canine mitral valve leaflets. J Cardiovasc Pharmacol 1999; 34: 254-260
• 11 Olsen LH, Fredholm M, Pedersen HD. Epidemiology and inheritance of mitral valve prolapse in Dachshunds. J Vet Intern Med 1999; 13: 448-456
• 12 Pedersen HD, Schutt T, Sondergaard R, Qvortrup K, Olsen LH, Kristensen AT. Decreased plasma concentration of nitric oxide metabolites in dogs with untreated mitral regurgitation. J Vet Intern Med 2003; 17: 178-184
• 13 Rozentryt P, Haehling S von, Lainscak M, Nowak JU, Kalantar-Zadeh K, Polonski L et al The effects of a high-caloric protein-rich oral nutritional supplement in patients with chronic heart failure and cachexia on quality of life, body composition, and inflammation markers: a randomized, double-blind pilot study. J Cachex Sarcopenia Muscle 2010; 1: 35-42
• 14 Sagols E, Priymenko N. Oxidative stress in dog with heart failure: the role of dietary fatty acids and antioxidants. Vet Med Int 2011; 2011: 180206
• 15 Smith CE, Freeman LM, Rush JE, Cunningham SM, Biourge V. Omega-3 fatty acids in Boxer dogs with arrhythmogenic right ventricular cardiomyopathy. J Vet Intern Med 2007; 21: 265-273
• 16 Swenson L, Haggstrom J, Kvart C, Juneja RK. Relationship between parental cardiac status in Cavalier King Charles spaniels and prevalence and severity of chronic valvular disease in offspring. J Am Vet Med Assoc 1996; 208: 2009-2012