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Horm Metab Res 2011; 43(2): 121-125
DOI: 10.1055/s-0030-1269853
Humans, Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Thyroid Hormones Affect Plasma Ghrelin and Obestatin Levels

J. Kosowicz1 , A. Baumann-Antczak1 , M. Ruchała1 , M. Gryczyñska1 , E. Gurgul1 , J. Sowiñski1
  • 1Department of Endocrinology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland
Further Information

Publication History

received 21.06.2010

accepted 10.11.2010

Publication Date:
16 December 2010 (online)

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Abstract

Using radioimmunoassay, the effects of thyroid hormones on plasma total ghrelin (Gh) and obestatin (Ob) concentrations were evaluated in thyrotoxic patients with an excess of thyroid hormones and in hypothyroid patients lacking endogenous thyroid hormones. 24 patients with thyrotoxicosis, 25 hypothyroid patents after total thyreoidectomy performed due to thyroid cancer, and 17 control subjects were examined. Compared with the controls, the ghrelin and obestatin were elevated in hypothyroidism, while they were decreased in thyrotoxicosis. The plasma Gh and Ob levels differ depending on the thyroid function. In thyroid hormones deficiency, plasma Gh and Ob are increased, while in patients with excess of thyroid hormones, the levels of both Gh and Ob are definitely lower. Gh/Ob ratio is higher in hypothyroidism than in control subjects and thyrotoxic patients.

Key words

thyroid hormones - ghrelin - obestatin

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Correspondence

J. Kosowicz

Department of Endocrinology,

Metabolism and Internal

Diseases

Poznan University of Medical

Sciences

Przybyszewskiego Street 49

60-355 Poznan

Poland

Phone: +48/61/8691330

Fax: +48/61/8691682

Email: endosk2@umed.poznan.pl