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Semin Reprod Med 2011; 29(1): 061-070
DOI: 10.1055/s-0030-1268705
© Thieme Medical Publishers

Stem Cell Therapy: A Future Treatment of Stress Urinary Incontinence

Dmitriy Nikolavasky1 , Klaudia Stangel-Wójcikiewicz2 , Malgorzata Stec2 , Michael B. Chancellor1
  • 1Department of Urology, William Beaumont Hospital, Royal Oak, Michigan
  • 2Department of Gynecology and Transplantology, Collegium Medicum Jagiellonian University of Kraków, Poland
Further Information

Publication History

Publication Date:
04 January 2011 (online)

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ABSTRACT

The main urinary continence mechanism in human is the striated muscle rhabdosphincter that forms a ring around the mid-urethra. Cellular therapy and the use of stem cells transplanted into the site of the rhabdosphincter in a setting of stress urinary incontinence (SUI) may augment sphincter regeneration. Implanted cells may also release trophic factors promoting muscle and nerve integration into this muscle. We review the use of cellular therapy for SUI and our experience with the development of muscle-derived stem cells.

KEYWORDS

Stress urinary incontinence - muscle-derived stem cells - stem cell therapy

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Michael B ChancellorM.D. 

Suite 438, 3535 West 13 Mile Road

Royal Oak, MI 48073

Email: Michael.chancellor@beaumont.edu

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