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Int J Sports Med 2011; 32(1): 14-19
DOI: 10.1055/s-0030-1267930
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

Gender-Specific Oxidative Stress Parameters

V. Dopsaj1 , 4 , J. Martinovic2 , M. Dopsaj3 , J. K. Stevuljevic4 , N. Bogavac-Stanojevic4
  • 1Clinical Centre of Serbia, Institute of Medical Biochemistry, Belgrade, Serbia
  • 2Belgrade Clinical Centre, Laboratory Department, Belgrade, Serbia
  • 3Faculty of Sport and Physical Education, Diagnostics and Analytics in Sports, Belgrade, Serbia
  • 4Faculty of Pharmacy, Institute of Medical Biochemistry, University of Belgrade, Serbia
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Publication History

accepted after revision September 23, 2010

Publication Date:
17 November 2010 (online)

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Abstract

The aim of the present study was to examine the association of proteins that regulate iron transport/storage content and acute phase response with oxidative stress in male and female athletes. Serum ferritin, transferrin, soluble transferrin receptor, C-reactive protein, interleukin-6 and oxidative stress parameters (reactive oxygen metabolites, superoxide anion, advanced oxidation protein products, lipid hydroperoxides, superoxide-dismutase and pro-oxidant-antioxidant balance) were determined in 138 athletes (73 females and 65 males). A general linear model indicated significant gender differences between athletes in terms of reactive oxygen metabolites (307.48±61.02 vs. 276.98±50.08; P=0.030), superoxide-dismutase (114.60±41.64 vs. 101.42±38.76; P=0.001), lipid hydroperoxides (149.84±38.95 vs. 101.43±39.26; P<0.001), pro-oxidant-antioxidant balance (512.40±148.67 vs. 413.09±120.30; P=0.002), advanced oxidation protein products (1.49±0.30 vs. 0.91±0.25; P<0.001) and superoxide (2.61±0.36 vs. 2.22±0.35; P=0.001), which were all significantly higher in females. Multivariate analysis of covariance indicated gender (P<0.001), training experience (P=0.004), C-reactive protein (P=0.002), soluble transferrin receptor (P=0.004) and transferrin (P<0.001) as significant covariates. Gender accounted for the largest proportion of variability for all oxidative stress parameters (46.3%) and female athletes were more susceptible to oxidative stress. Iron transport and storage proteins (transferrin and ferritin), but also acute phase reactants, were negatively related factors for oxidative stress. In conclusion, variation in the ferritin level may contribute to the different oxidative stress level between the sexes.

Key words

free radicals - ferritin - transferrin - acute phase response - superoxide-dismutase

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Correspondence

Dr. Jelena Martinovic

Belgrade Clinical Centre

Laboratory Department

Milutina Milankovica 3

11000 Belgrade

Serbia

Phone: +381/11/3313 855

Fax: +381/11/3313 855

Email: jelena.martinovic@bgdkbc.com

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