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DOI: 10.1055/s-0030-1260946
A Journey through 12 Years
of Interacting Molecules: From Artificial Amino Acid Receptors to
the Recognition of Biomolecules and Switchable
Nanomaterials
Publication History
Publication Date:
14 July 2011 (online)
![](https://www.thieme-connect.de/media/synlett/201113/lookinside/thumbnails/10.1055-s-0030-1260946-1.jpg)
Abstract
Research in supramolecular chemistry has been carried out in my laboratory for the past 12 years. Intrigued by the fascinating power of supramolecular chemistry, as seen in biomolecular recognition events in nature, we started out by trying to mimic the basic principles of such recognition events in small artificial model systems. Our first targets were amino acids and oligopeptides. We then moved on to proteins and nucleic acids, and we started to develop supramolecular systems that, besides simple binding, also featured functions, e.g. shutting down enzymes or allowing gene delivery into cells. In recent years and in a completely different yet related field, we have begun to develop self-assembling nanomaterials. The basic idea for this derived from an accidental discovery of the interesting self-assembling properties of a simple zwitterion, which was a synthetic intermediate on the route to our amino acid receptors. This personal account summarizes this journey and is intended not only to present the most-important findings from our laboratory so far, but also to shed light on how all these projects developed over the years and how our journey took us to where we are now.
1 Introduction
2 How It All Began
3 The Beginning: The Design of a New Oxoanion Binding Site
4 Tailor-Made Receptors for Small Peptides
5 Combinatorial Development of Peptide Receptors
6 From Small Peptides to Proteins
7 Nucleic Acids as Targets
8 Self-Assembling Zwitterions
9 pH-Switchable Nanostructures
10 Conclusion
Key words
supramolecular chemistry - molecular recognition - self-assembly - host-guest chemistry - combinatorial chemistry
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References
The term ‘Gulliver effect’ is often used in supramolecular chemistry to describe the simultaneous effect of several weak interactions for binding a substrate: See also ref. 8a