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Synfacts 2011(9): 0933-0933  
DOI: 10.1055/s-0030-1260910
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of a CRF-1 Receptor Antagonist

Contributor(s): Philip Kocienski
K. J. Hodgetts et al.*
Neurogen Corporation, Branford, USA
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Publication History

Publication Date:
19 August 2011 (online)

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Significance

Corticotropin releasing factor-1 (CRF-1) antagonists are potential antidepressants and anxiolytic agents. The target molecule is an orally active CRF-1 antagonist with good brain penetration, but further development was halted owing to its long half-life and potential to accumulate in adipose tissues.