Cu-Catalyzed 1H-Perfluoroalkane
Arylation by Aryl Iodide

doi:10.1055/s-0030-1260884

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Synfacts 2011(9): 0999-0999
DOI: 10.1055/s-0030-1260884

Metal-Mediated Synthesis

Cu-Catalyzed 1H-Perfluoroalkane Arylation by Aryl Iodide

Contributor(s): Paul Knochel, Andreas K. Steib
I. Popov, S. Lindeman, O. Daugulis*
University of Houston and Marquette University, Milwaukee, USA

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Publication History

Publication Date:
19 August 2011 (online)

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Significance

A new method for the arylation of readily available 1H-perfluoroalkanes has been disclosed. 1H-Perfluoroalkanes are deprotonated by TMP₂Zn (TMP= 2,2,6,6-tetramethylpiperidyl), transmetalated with copper chloride and subsequently cross-coupled with various aryl iodides.