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Synfacts 2011(7): 0736-0736
DOI: 10.1055/s-0030-1260660
DOI: 10.1055/s-0030-1260660
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Rh-Catalyzed Asymmetric Cycloaddition of Imines and Isocyanates
K. M. Oberg, T. Rovis*
Colorado State University, Fort Collins, USA
Further Information
Publication History
Publication Date:
17 June 2011 (online)
Significance
The current work represents a novel synthesis of pyrimidinones from α,β-unsaturated imines and isocyanates using a rhodium/phosphoramidite catalyst system. The corresponding products can be obtained with good yields and high enantioselectivities.