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Synthesis 2011(8): 1302-1308
DOI: 10.1055/s-0030-1259966
DOI: 10.1055/s-0030-1259966
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Functionalization of the Benzo[c][1,2,5]thiadiazole Scaffold via Mg-, Zn- and Mn-Intermediates
Further Information
Received
28 January 2011
Publication Date:
24 March 2011 (online)
Publication History
Publication Date:
24 March 2011 (online)
![](https://www.thieme-connect.de/media/synthesis/201108/lookinside/thumbnails/10.1055-s-0030-1259966-1.jpg)
Abstract
The metalation of all positions of the benzo[c][1,2,5]thiadiazole scaffold using LiCl-solubilized TMP-bases is demonstrated on various substrates. Thus, unsymmetrically substituted benzothiadiazole derivatives and a new fused thiadiazoloindazole have been prepared.
Key words
organometallic reagents - metalation - bicyclic compounds - heterocycles - benzo[c][1,2,5]thiadiazole
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