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Synfacts 2011(3): 0246-0246  
DOI: 10.1055/s-0030-1259408
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Streptolydigin

Contributor(s): Steven V. Ley, Catherine F. Carter
S. V. Pronin, S. A. Kozmin*
The University of Chicago, USA
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Publication History

Publication Date:
16 February 2011 (online)

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Significance

Streptolydigin is a highly potent broad-spectrum antibiotic isolated from Strep­tomyces lydicus. It displays inhibitory activity against bacterial RNA polymerase with a distinct mode of action compared with the rifamycins that are commonly used to treat tuberculosis.