Download PDF
Synfacts 2010(10): 1175-1175  
DOI: 10.1055/s-0030-1258604
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Two-Component Cyclization to N-Fused Pyrroles

Contributor(s): Paul Knochel, Thomas Kunz
D. Chernyak, C. Skontos, V. Gevorgyan*
University of Illinois at Chicago, USA
Further Information

Publication History

Publication Date:
22 September 2010 (online)

    Permissions and Reprints

Significance

A synthetical route to N-fused ­pyrroloheterocycles by a palladium-catalyzed, two-component reaction is described. In this cascade, a cross-coupling reaction of an aryl halide with a propagylic ester or ether is followed by a 5-endo-dig cyclization leading to various fully-substituted pyrroles.