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Synthesis 2011(1): 127-132
DOI: 10.1055/s-0030-1258346
DOI: 10.1055/s-0030-1258346
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
An Alternative Synthesis of 2-Alkylidene-3,4-dihydro-2H-1,4-benzoxazines by Intramolecular Gold-Catalyzed Hydroalkoxylation of 2-(Prop-2-yn-1-ylamino)phenols
Further Information
Received
7 October 2010
Publication Date:
01 December 2010 (online)
Publication History
Publication Date:
01 December 2010 (online)
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Abstract
An efficient gold-catalyzed procedure to synthesize 2-alkylidene-3,4-dihydro-2H-1,4-benzoxazines has been developed starting from 2-alkynyl-substituted phenols. This is an intramolecular hydroalkoxylation reaction on alkynes tethered to a phenol moiety that represents a valuable alternative to the already reported transition-metal-catalyzed procedures.
Key words
transition metals - heterocycles - alkynes - phenols - fused-ring systems
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