Synlett 2010(15): 2311-2313  
DOI: 10.1055/s-0030-1258034
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

One-Pot Synthesis of Substituted Pyrimidine Derivatives from Acetylenedicarboxylate, Amine and Orthoformate

Arasampattu S. Nagarajan, Boreddy S. R. Reddy*
Industrial Chemistry Laboratory, Central Leather Research Institute, Adyar, Chennai 600 020, India
Fax: +91(44)24911589; e-Mail: induchem2000@yahoo.com;
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Publication History

Received 28 June 2010
Publication Date:
12 August 2010 (online)

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Abstract

Substituted pyrimidine derivatives with a disubstituted pattern are produced in a novel one-pot reaction from diethyl(methyl)acetylenedicarboxylate, amine, and trimethyl(ethyl)orthoformate under solvent-free conditions using ZnCl2 catalyst.