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Synfacts 2010(9): 1062-1062
DOI: 10.1055/s-0030-1257903
DOI: 10.1055/s-0030-1257903
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Regioselective Hydroarylation of Protected Allylic Amines
G. C. Tsui, F. Menard, M. Lautens*
University of Toronto, Canada
Further Information
Publication History
Publication Date:
23 August 2010 (online)
Significance
A rhodium(I)-catalyzed hydroarylation of unactivated alkenes with arylboronic acids is reported. The regioselectivity of the addition is highly dependent on the protecting group and the carbon chain length of the allylic amine.