Planta Med 2011; 77(1): 95-100
DOI: 10.1055/s-0030-1250133
Biological Screening
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioides

Mariana B. Joray1 , María R. del Rollán2 , Gustavo M. Ruiz3 , Sara M. Palacios1 , María C. Carpinella1
  • 1Fine Chemicals and Natural Products Laboratory, School of Chemistry, Catholic University of Córdoba, Córdoba, Argentina
  • 2Bacteriology Laboratory, School of Chemistry, Catholic University of Córdoba, Córdoba, Argentina
  • 3Herbarium Marcelino Sayago, School of Agricultural Science, Catholic University of Córdoba, Córdoba, Argentina
Further Information

Publication History

received March 15, 2010 revised June 14, 2010

accepted June 17, 2010

Publication Date:
19 July 2010 (online)

Abstract

The great increase in bacterial infections is fueling interest in the search for antibacterial products of plant origin. Extracts obtained from 51 native and naturalized plants from central Argentina were therefore evaluated for their in vitro inhibitory activity on pathogenic bacteria with the aim of selecting the most active ones as new sources of effective antibiotics. The susceptibility of reference and clinical strains of Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella enterica serovar Enteritidis, and Staphylococcus aureus was determined. Extracts from Achyrocline satureioides, Flourensia oolepis, Lepechinia floribunda, and Lithrea molleoides were the most potent, with MIC and MBC values ranging from 0.006 to 2 and 0.012 to 10 mg/mL, respectively, on both gram-positive and negative bacteria. The antibacterial activity-guided isolation of A. satureioides ethanol extract showed 23-methyl-6-O-desmethylauricepyrone (1) to be the most active compound. This compound showed inhibitory effects against gram-positive bacteria with MIC and MBC values of 0.002 and 0.008 mg/mL, respectively, while on gram-negative strains, the MIC and MBC were 0.062–0.250 and 0.062–0.500 mg/mL, respectively. The strong antibacterial activity shown by the four plant extracts or the compound isolated from A. satureioides suggests that they could become part of the arsenal of antibacterial drugs currently used.

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Prof. Dr. María C. Carpinella

Laboratorio de Química Fina y Productos Naturales
Facultad de Ciencias Químicas
Universidad Católica de Córdoba

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5000 Córdoba

Argentina

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