Exp Clin Endocrinol Diabetes 2010; 118(10): 757-759
DOI: 10.1055/s-0030-1249686
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The rs1800629 Polymorphism in the TNF Gene Interacts with Physical Activity on the Changes in C-reactive Protein Levels in the Finnish Diabetes Prevention Study

T. O. Kilpeläinen1 , D. E. Laaksonen1 , 2 , T. A. Lakka1 , 3 , C. Herder4 , W. Koenig5 , J. Lindström6 , J. G. Eriksson6 , 7 , 8 , 9 , M. Uusitupa10 , H. Kolb4 , M. Laakso2 , J. Tuomilehto6 , 7 , 11 for the Finnish Diabetes Prevention Study Group
  • 1Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
  • 2Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
  • 3Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
  • 4Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
  • 5Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany
  • 6Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
  • 7Department of Public Health, University of Helsinki, Helsinki, Finland
  • 8Vasa Central Hospital, Vasa, Finland
  • 9Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland
  • 10School of Public Health and Clinical Nutrition, Clinical Nutrition, University of Kuopio, Kuopio, Finland
  • 11South Ostrobothnia Central Hospital, Seinäjoki, Finland
Further Information

Publication History

received 17.01.2010 first decision 17.01.2010

accepted 08.03.2010

Publication Date:
01 April 2010 (online)

Abstract

Physical activity exerts anti-inflammatory effects, but genetic variation may modify its influence. In particular, the rs1800629 single-nucleotide polymorphism (SNP) in the tumor necrosis factor (TNF) gene and the rs1800795 SNP in the interleukin-6 (IL6) gene have been found to modify the effect of exercise training on circulating levels of C-reactive protein (CRP) and IL-6, respectively. We assessed whether rs1800629 and rs1800795 modified the effect of moderate-to-vigorous physical activity on changes in serum levels of high-sensitivity CRP and IL-6 in the Finnish Diabetes Prevention Study (DPS). Genotype and 1-year data on changes in physical activity, serum CRP and IL-6 were available for 390 overweight subjects with impaired glucose tolerance. The rs1800629 SNP in TNF interacted with the 1-year change in moderate-to-vigorous physical activity on changes in CRP among those who had high (≥3 mg/L) baseline CRP levels (P=0.034 for interaction). Carriers of the GG genotype showed a greater decrease in CRP with increasing physical activity than the individuals with the A allele. No interaction between the rs1800795 SNP in IL6 and changes in moderate-to-vigorous physical activity on the 1-year change in serum IL–6 was found. In conclusion, the rs1800629 SNP in the TNF gene may modify the effect of moderate-to-vigorous physical activity on serum levels of CRP.

References

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Correspondence

T. O. Kilpeläinen

MRC Epidemiology Unit

Institute of Metabolic Science

Box 285

Addenbrooke's Hospital

Hills Road

CB2 0QQ Cambridge

United Kingdom

Phone: +44/01223/7691 64

Fax: +44/01223/3303 16

Email: tuomas.kilpelainen@mrc-epid.cam.ac.uk