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Int J Sports Med 2010; 31(7): 458-462
DOI: 10.1055/s-0030-1249623
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

The Influence of Acute Resistance Training and Body Composition on Coagulation and Fibrinolytic Activity in Low-Risk Women

P. R. Nagelkirk1 , R. Scalzo2 , M. Harber3 , L. A. Kaminsky3
  • 1Ball State University, School of Physical Education, Sport & Exercise Science, Muncie, United States
  • 2Ball State University, Clinical Exercise Physiology, Muncie, United States
  • 3Ball State University, Human Performance Laboratory, Muncie, United States
Further Information

Publication History

accepted after revision February 06, 2010

Publication Date:
29 April 2010 (online)

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Abstract

This study explored the coagulation and fibrinolytic responses to acute resistance training in young women and aimed to determine the influence of body composition on these variables. Healthy young women aged 23±5 yrs participated in the study. Body fat and fat distribution were assessed using DEXA. Each subject performed 6 sets of 10 leg extension repetitions at an intensity associated with 70% of 1-repetition maximum. Markers of coagulation (TAT), fibrinolytic stimulation (tPA) and inhibition (PAI-1) were assessed before and immediately after exercise. tPA activity increased in response to acute resistance exercise (p<0.05), however, there was no change in TAT or PAI-1 activity. Percent body fat was negatively correlated to the tPA response to exercise (r=−0.44), and positively related to PAI-1 at baseline (r=0.47) and post-exercise (r=0.47), and to post-exercise TAT (r=0.44). Android/gynoid fat ratio was negatively related to post-exercise tPA (r=−0.43), positively related to PAI-1 at baseline (r=0.61) and post-exercise (r=0.62) and to post-exercise TAT (r=0.43). These physiological responses suggest women with elevated body fat may be at increased risk of an adverse thrombosis-related event both at rest and during exercise compared to leaner women.

Key words

tissue plasminogen activator - plasminogen activator inhibitor - thrombin - antithrombin

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Correspondence

Prof. Paul R. Nagelkirk

Ball State University

School of Physical Education

Sport & Exercise Science

HP 215

47306 Muncie

United States

Phone: +1/765/285 1472

Fax: +1/765/285 8254

Email: prnagelkirk@bsu.edu

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