Prophylaxis in Congenital Hemophilia with Inhibitors: The Role of Recombinant Activated Factor VII

Massimo Franchini; Franco Manzato; Gian Luca Salvagno; Martina Montagnana; Marco Zaffanello; Giuseppe Lippi

doi:10.1055/s-0029-1245114

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Semin Thromb Hemost 2009; 35(8): 814-819
DOI: 10.1055/s-0029-1245114

Prophylaxis in Congenital Hemophilia with Inhibitors: The Role of Recombinant Activated Factor VII

Massimo Franchini¹ , Franco Manzato² , Gian Luca Salvagno³ , Martina Montagnana³ , Marco Zaffanello⁴ , Giuseppe Lippi⁵

¹Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma
²Laboratorio di Patologia Clinica, Ospedale “Carlo Poma”, Mantova
³Sezione di Chimica Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Università di Verona, Verona
⁴Dipartimento Materno-Infantile e di Biologia Genetica; Verona
⁵Unità Operativa di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma; Italy

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Publication Date:
18 February 2010 (online)

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ABSTRACT

The development of inhibitors against therapeutically administered factors VIII or IX is actually the most challenging complication of hemophilia patients with inhibitors. The introduction of bypassing agents (i.e., activated prothrombin complex concentrates and recombinant activated factor VII [rFVIIa]) has dramatically improved the management of bleeding episodes in such patients. Over the last decade, there have been increasing reports on the ability of bypassing agents to prevent surgical, joint, or other bleeds in inhibitor patients. The published data on the use of rFVIIa as a prophylactic treatment in hemophilia patients with inhibitors are reviewed in this article.

KEYWORDS

rFVIIa - prophylaxis - surgery - bleeding

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Dr. Massimo FranchiniM.D.

Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio

Azienda Ospedaliero-Universitaria di Parma, Parma, Italy

Email: massimo.franchini@azosp.vr.it